The Nuclear Protein Database
The Nuclear Protein Database (NPD) is a searchable database of information on proteins
that are localised to the nucleus of vertebrate cells.
How to use the NPD
You can search the whole database using a protein name, protein motif, nuclear compartment name, or keyword term. Alternatively you can view all of the proteins that have been reported as having a localisation to a particular compartment or that are associated with a particular protein domain, using the nuclear compartment and domain browsers. An introduction to each of the principal sub-nuclear compartments is also provided.
What is in the NPD?
The NPD contains information on over 1000 vertebrate proteins (mainly those from mouse and
human) that are thought to, or known to, be localised to the cell nucleus. Where known, the
sub-nuclear compartment where the proteins have been found are reported. Also stored is
information on the amino acid sequence, predicted protein size and isoelectric point, as well as any repeats, motifs or domains within the protein sequence. Biological and molecular
functions of the proteins are described using GO terms. Where appropriate, links to other
databases are provided (e.g. Entrez, SWISS-PROT, OMIM, PubMed, PubMed Central).
What is not in the NPD?
In general only one isoform of the protein is given (usually the largest). The database contains
no information on protein isoforms generated by alternative splicing.