Names
Name
Species
Main
F9/29A6 
Mus musculus 
True 
NBS1 
Gallus gallus, Homo sapiens, Mus musculus 
False 
Nibrin 
Mus musculus 
False 
p95 
Homo sapiens 
False 
Keywords
acute lymphoblastic leukemia ALL, APB, ATM phosphorylation, BRCA1 nuclear dots, brct, cancer, chromosome breakage, chromosome instability, ds break repair, gene trap, homologous recombination, Ig class switching, immunodeficiency, Irradiation induced foci, MRE11, Nijmegen breakage syndrome, PML bodies, RAD50, radiation sensitivity, forkhead associated domain, alt, end resection
Location
Location
Species
8q21 
Homo sapiens 
Mus musculus 
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
repair foci 
gene trap protein in foci in some cells, diffuse in most 
Interphase 
IR-induced foci 
Complex with RAD50 and MRE1. To sites of P-H2A-X after damage 
Interphase 
telomere 
Complex with TRF2 and telomeres in telomerase negative cells 
S - meiosis 
PML/ND10 bodies 
Required to localise MRE11 in late S/G2 in telomerase negative cells 
meiosis 
telomere 
 
G2 
PML/ND10 bodies 
in telomerase negative cells 
Interphase 
T cell receptor alpha locus 
in thymocytes 
Interphase 
immunoglobulin heavy-chain constant region 
in B cells 
S - interphase 
replication foci 
 
Interphase 
ALT-associated PML body 
 
Interphase 
nucleolus 
upon DNA damage 
Annotation
Start
End
Domain
Description
754 
full length 
 
23 
100 
FHA 
 
105 
190 
BRCT (breast cancer susceptibility protein signatu 
 
278 
 
phosphorylated serine 
phosphorylation site 
343 
 
phosphorylated serine 
phosphorylation site by ATM 
397 
 
phosphorylated serine 
phosphorylation site by ATM 
615 
 
phosphorylated serine 
phosphorylation site by ATM 
751 
full length 
 
23 
83 
FHA 
 
103 
184 
BRCT (breast cancer susceptibility protein signatu 
 
461 
467 
NLS 
 
545 
552 
NLS 
 
588 
592 
NLS 
 
Biological Process
GO ID
Term
Links
GO:0006310 
DNA recombination 
GO:0007095 
mitotic G2 checkpoint 
GO:0006974 
response to DNA damage stimulus 
GO:0007004 
telomerase-dependent telomere maintenance 
GO:0016447 
somatic recombination of antibody genes 
GOIDHERE 
replication 
GO:0006302 
double-strand break repair 
GO:0000724 
double-strand break repair via homologous recombination 
Molecular Function
GO ID
Term
Links
Other Function
Function
Links
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
History
Created On
Last Changed
2001-01-05 16:20:36 
2005-05-04 12:51:29