Names
X
Name
Species
Main
PML 
Homo sapiens, Mus musculus 
True 
TRIM19 
 
False 
Keywords
X
APB, apoptosis, cancer, DNA repair, histone deacetylase complex, leukaemia, leukaemia_associated translocation, telomere, nucleolus, PML bodies, RBCC, SUMO, zinc finger B_box, ER, alt, telomere maintenance
Location
X
Location
Species
15q22 
Homo sapiens 
9 
Mus musculus 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
PML/ND10 bodies 
relatively immobile 
PubMed:11238464
Interphase 
nucleolar 
upon proteosome inhibition by MG132, or phosphorylation by ATR 
PubMed:15195100
PubMed Central:11158586
Interphase 
repair foci 
 
PubMed:12642865
Interphase 
ALT-associated PML body 
enlarged PML body in ALT cells 
PubMed:15075340
pachytene 
XY body 
 
PubMed:15349788
Interphase 
clastosome 
 
PubMed:16818720
Interphase 
endoplasmic reticulum 
 
pubmed:21030605
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
97.5 
5.88 
 
 
882 
Entrez Protein:P29590
OMIM:102578
Uniprot:P29590
90 
5.38 
 
 
808 
PubMed: 96116962
Entrez Nucleotide: NM_008884
Annotation
X
Start
End
Domain
Description
1 
633 
full length 
 
57 
91 
RING finger 
 
124 
166 
B-Box Zn finger 
 
1 
808 
full length 
 
31 
65 
RING finger 
 
98 
140 
B-Box Zn finger 
 
Biological Process
X
GO ID
Term
Links
GO:0006342 
chromatin silencing 
PubMed:11259576
GO:0006325 
establishment and/or maintenance of chromatin architecture 
PubMed:17173041
GO:0006918 
induction of apoptosis by p53 
PubMed:14992722
PubMed:12907596
pubmed:21030605
GO:0000122 
negative regulation of transcription from Pol II promoter 
GO:0032205 
regulation of telomere maintenance 
pubmed:1956747
pubmed:25908860
Molecular Function
X
GO ID
Term
Links
Other Function
X
Function
Links
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
History
X
Created On
Last Changed
2001-03-26 12:04:15 
2007-07-27 11:15:39