Names
Name
Species
Main
gemin 
 
False 
SMN1 
Homo sapiens 
True 
Keywords
Cajal body, gem, genetic disease, nuclear mRNA splicing via spliceosome, methylated H3K79 binding
Location
Location
Species
13 
Mus musculus 
5q13 
Homo sapiens 
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
gems 
move from cytoplasm to nucleus in response to serum 
Interphase 
Cajal bodies 
In most cultured cells and all 1o neurons. Requires sDMA-modified protein. Accumulates during diff. 
Interphase 
cytoplasmic 
interact with the Sm core proteins 
Interphase 
nucleolar 
gems in side nucleoli in half of adult tissues and 30% fetal tissues. Mutant form in nucleolus 
Interphase 
perinucleolar 
SMN in large bodies at nucleolar perimeter in motor neurons. Nucleolar periphery on Pol I inhibition 
Annotation
Start
End
Domain
Description
70 
80 
NLS 
 
90 
149 
tudor 
SMA mutation E134K abolishes binding to Sm 
Biological Process
GO ID
Term
Links
GO:0030576 
Cajal body organization and biogenesis 
GO:0007399 
neurogenesis 
GO:0000398 
nuclear mRNA splicing, via spliceosome 
GO:0016074 
snoRNA metabolism 
Molecular Function
GO ID
Term
Links
GO:0003682 
chromatin binding 
GO:0035064 
methylated histone residue binding 
Other Function
Function
Links
modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons 
Expression
Related Genes
Name
Species
Links
Yab8p 
Schizosaccharomyces pombe 
History
Created On
Last Changed
2001-04-04 11:22:34 
2006-07-12 09:56:25