Names
X
Name
Species
Main
lamin A/C 
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus 
True 
Keywords
X
farnesylation, intermediary filament, replication origin, nuclear periphery
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nuclear periphery 
nuclear lamina 
PubMed:15596010
G1 
replication origins 
earliest replication origins of primary cells 
PubMed:11090133
PubMed:7738105
S - interphase 
replication origins 
earliest replication origins of primary cells 
PubMed:11090133
G1 
perinucleolar 
earliest replication origins of primary cells are often perinucleolar 
PubMed:11090133
S - meiosis 
perinucleolar 
earliest replication origins of primary cells are often perinucleolar 
PubMed:11090133
G1 
repair foci 
intranuclear foci esp early G1 
PubMed:10984438
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
74.2 
6.54 
70 
 
665 
PubMed:10579712
Entrez Protein:NP_001002011
Uniprot:P48678
74.1 
6.57 
70 
 
664 
PubMed:10739764
PubMed:10587585
PubMed:10080180
PubMed:11257219
PubMed:10814726
PubMed:10655060
PubMed:11112685
PubMed:15317753
OMIM:604929
OMIM:181350
OMIM:159001
OMIM:151660
OMIM:115200
Entrez Protein:NP_733821
Uniprot:P02545
65.4 
6.37 
 
 
574 
Entrez Protein:BAA08570
Uniprot:P11516
65.1 
6.4 
 
 
572 
Entrez Protein:VEHULC
 
 
 
 
657 
Entrez Protein:P13648
Uniprot:P13648
 
 
 
 
665 
Entrez Protein:P48679
Uniprot:P48679
Annotation
X
Start
End
Domain
Description
30 
386 
filament 
 
219 
222 
NLS 
 
408 
545 
IF_tail 
 
417 
420 
NLS 
 
662 
665 
farnesylation CaaX motif 
 
219 
222 
NLS 
 
417 
420 
NLS 
 
661 
664 
farnesylation CaaX motif 
 
219 
222 
NLS 
 
417 
420 
NLS 
 
219 
222 
NLS 
 
417 
420 
NLS 
 
Biological Process
X
GO ID
Term
Links
GO:0006997 
nuclear organization and biogenesis 
PubMed:11503164
PubMed:10579712
PubMed:11792811
PubMed:15184648
PubMed:15367494
PubMed:15317753
PubMed:12714972
PubMed:12702809
PubMed:12748643
PubMed:16126733
PubMed Central:14755333
pubmed:1860684
GO:0046716 
muscle cell homeostasis 
pubmed:21364987
Molecular Function
X
GO ID
Term
Links
Other Function
X
Function
Links
adipocyte differentiation 
PubMed:16415042
Expression
X
Experiment
Detail
Links
Immunofluorescence 
lamin A present in dermal fibroblasts and in suprabasal epithelial cells of skin 
PubMed:11207047
Immunofluorescence 
lamin A absent from all basal epithelial cells of skin 
PubMed:11207047
Immunofluorescence 
Lamin C expressed in dermal fibroblasts, suprabasal epithelial cells and a majority of basal epithelial cells. 
PubMed:11207047
Immunofluorescence 
Lamin C absent from quiescent basal epithelial cells of skin 
PubMed:11207047
 
present in ESCs 
pubmed:23324457
Related Genes
X
Name
Species
Links
lmn-1 
Caenorhabditis elegans 
PubMed:11071918
History
X
Created On
Last Changed
2001-04-09 15:41:05 
2006-03-06 09:35:07