Names
+
Keywords
X
aneuploidy, cancer, kinase, neocentromere, serine threonine kinase, spindle checkpoint, genetic disease
Location
X
Location
Species
15q15 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
metaphase - mitosis 
kinetochore 
needs bub3, interacts with CenP-E. present on neocentromeres 
PubMed:10477750
PubMed:10607828
PubMed:15561729
PubMed:98437347
PubMed:9914370
PubMed:98327111
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
119.5 
5.17 
 
 
1050 
Entrez Protein:O60566
PubMed:15475955
PubMed:98180623
OMIM:602860
Uniprot:O60566
 
 
 
 
1052 
Entrez Protein:Q9Z1S0
Uniprot:Q9Z1S0
Annotation
X
Start
End
Domain
Description
438 
454 
NLS 
 
755 
1023 
S_TKc 
 
Biological Process
X
GO ID
Term
Links
GO:0000075 
cell cycle checkpoint 
GO:0000077 
DNA damage checkpoint 
PubMed:16449973
GO:0007093 
mitotic checkpoint 
PubMed:10593653
PubMed Central:11274370
GO:0007049 
cell cycle 
GO:0007059 
chromosome segregation 
PubMed:15208629
PubMed:15592459
PubMed:15475955
pubmed:31738183
GO:0001301 
progressive alteration of chromatin during cell aging 
PubMed:15208629
Molecular Function
X
GO ID
Term
Links
GO:0004674 
protein serine/threonine kinase activity 
Other Function
X
Function
Links
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
Bub1 
Saccharomyces cerevisiae 
Mad3 
Saccharomyces cerevisiae 
History
X
Created On
Last Changed
2001-04-10 15:24:29 
2006-03-09 11:49:10