Names
Name
Species
Main
KIAA0178 
 
False 
SB1.8 
Homo sapiens 
False 
SMC1 
Homo sapiens 
True 
SMC1 like 1 
Homo sapiens 
False 
SMC1alpha 
 
False 
SMC1L1 
 
False 
SMCB 
Mus musculus 
False 
Keywords
ATPase, DNA damage, genetic disease, heterodimer, cohesion, meiotic chromosomes, meiotic prophase, myosin, SMC, Wiedemann-Steiner syndrome, CdLS, holoprosencephaly
Location
Location
Species
Xp11.22-p11.21 
Homo sapiens 
Mus musculus 
Subcellular Localisation
Stage
Description
Details
Links
meiosis 
chromatin 
intense in meiotic prophase cells, weaker in round spermatids. Absent from elongated spermatids 
meiosis 
axial elements of synaptonemal complex 
Beaded structure in spermatocyte nuclei spreads at pachytene and diplotene. Also in oocytes 
Interphase 
diffuse 
 
metaphase - meiosis I 
centromere 
 
Annotation
Start
End
Domain
Description
161 
SMC N term 
 
32 
39 
ATP_GTP binding site motif A 
 
170 
173 
NLS 
 
187 
190 
NLS 
 
253 
270 
NLS BP 
 
297 
490 
myosin tail 
 
316 
332 
NLS BP 
 
453 
469 
NLS BP 
 
664 
693 
NLS BP 
 
688 
929 
myosin tail 
 
1006 
1220 
SMC C term 
 
1050 
1066 
NLS BP 
 
1118 
1124 
NLS 
 
1128 
1200 
DA box 
 
Biological Process
GO ID
Term
Links
GO:0006281 
DNA repair 
GO:0007126 
meiosis 
GO:0007066 
female meiosis sister chromatid cohesion 
GO:0007065 
male meiosis sister chromatid cohesion 
GO:0007064 
mitotic sister chromatid cohesion 
GO:0007062 
sister chromatid cohesion 
GO:0031572 
G2/M transition DNA damage checkpoint 
Molecular Function
GO ID
Term
Links
GO:0004002 
ATPase activity 
Other Function
Function
Links
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
SMC1 
Saccharomyces cerevisiae 
XSMC1 
Xenopus laevis 
Psm1 
Schizosaccharomyces pombe 
HIM-1 
Caenorhabditis elegans 
SMC1 
Drosophila melanogaster 
History
Created On
Last Changed
2001-04-11 10:20:21 
2006-06-06 09:34:19