Names
Name
Species
Main
HCAP 
Homo sapiens 
False 
SMC3 
Homo sapiens 
True 
SMCD 
Mus musculus 
False 
Keywords
ATPase, heterodimer, cohesion, telomere, meiotic chromosomes, meiotic prophase, SMC, DNA damage, genetic disease, Wiedemann-Steiner syndrome, CdLS, holoprosencephaly
Location
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
diffuse 
 
meiosis 
axial elements of synaptonemal complex 
Beaded structure in spermatocyte nuclei spreads at pachytene and diplotene + oocytes 
meiosis 
chromatin 
intense in meiotic prophase cells, weaker in round spermatids. Absent from elongated spermatids 
metaphase - meiosis I 
centromere 
 
meiosis 
telomere 
depends on SMC1beta 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Start
End
Domain
Description
165 
SMC N term 
 
32 
39 
ATP_GTP binding site motif A 
 
396 
413 
NLS BP 
 
969 
1203 
SMC C term 
 
Biological Process
GO ID
Term
Links
GO:0007126 
meiosis 
GO:0007064 
mitotic sister chromatid cohesion 
GO:0031572 
G2/M transition DNA damage checkpoint 
Molecular Function
GO ID
Term
Links
GO:0004002 
ATPase activity 
Other Function
Function
Links
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
SMC3 
Saccharomyces cerevisiae 
XSMC3 
Xenopus laevis 
Psm3 
Schizosaccharomyces pombe 
SMC-3 
Caenorhabditis elegans 
SMC3 
Drosophila melanogaster 
History
Created On
Last Changed
2001-04-11 11:36:49 
2004-05-26 10:10:19