Names
Name
Species
Main
BRCA1 
Homo sapiens 
True 
FANCS 
 
false 
Keywords
APB, brct, cancer, chromatin remodelling, chromosome instability, heterochromatin, DNA damage, ds break repair, genetic disease, homologous recombination, Irradiation induced foci, swi_snf, transcription_coupled repair, tumour suppressor, ubiquitin ligase, X inactivation, retrotransposon silencing, alt, interstrand crosslinks, DNA repair, nucleolus, Fanconi Anemia, R loops, alternative end-joining, transcription repression, heterochromatin, H2A ubiquitination, genome stability, replication fork stability
Location
Location
Species
17q21 
Homo sapiens 
11 
Mus musculus 
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
BRCA1 nuclear dots 
Colocalises with FANCD2 
Interphase 
IR-induced foci 
localises to radiation induced foci (phosphorylated H2A-X) together with rad50, mre11, nbs 
S/G2 
repair foci 
after DNA damage with BLM 
Interphase 
inactive X 
Necessary for localising XIST 
Interphase 
ALT-associated PML body 
 
Interphase 
chromatin 
BRCA1-IRES isoform 
pachytene 
XY body 
 
Interphase 
centrosome 
after microtubule damage 
Interphase 
nucleolus 
 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Biological Process
GO ID
Term
Links
GO:0006338 
chromatin remodeling 
GO:0006342 
chromatin silencing 
GO:0006302 
double-strand break repair 
GO:0000122 
negative regulation of transcription from Pol II promoter 
GO:0006283 
transcription-coupled nucleotide-excision repair 
GO:0000067 
DNA replication and chromosome cycle 
GO:0000019 
regulation of mitotic recombination 
GO:0006357 
regulation of transcription from Pol II promoter 
GO:0070870 
heterochromatin maintenance involved in chromatin silencing 
GO:2000730 
regulation of termination of RNA polymerase I transcription 
GO:0097681 
double-strand break repair via alternative nonhomologous end joining 
GO:0048478 
replication fork protection 
GO:0017148 
negative regulation of translation 
Molecular Function
GO ID
Term
Links
GO:0003677 
DNA binding 
GO:0003723 
RNA binding 
GO:0004842 
ubiquitin-protein ligase activity 
GO:0035518 
histone H2A monoubiquitination 
Other Function
Function
Links
chromosome instability in -/- cells 
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
brc-1 
Caenorhabditis elegans 
History
Created On
Last Changed
2001-04-12 13:54:13 
2005-11-02 14:55:39