Names
X
Name
Species
Main
ATLD 
 
False 
MRE11 
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus 
True 
MRE11A 
Homo sapiens 
False 
Keywords
X
APB, ATM, BRCA1 nuclear dots, cancer, chromosome breakage, chromosome instability, dna damage response, heterodimer, Ig hypermutation, Irradiation induced foci, telomere, nuclear foci, exonuclease, PML bodies, radiation sensitivity, molecular clamp, alt, alternative end-joining, ciliopathy, genetic disease, end resection
Location
X
Location
Species
11q21 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
S - meiosis 
PML/ND10 bodies 
co-localisation with TRF1 in late S/G2 
PubMed:10913111
Interphase 
IR-induced foci 
to H2A-X foci after DNA damage together with brca1, rad50, nbs1 
PubMed:11113202
PubMed:10426999
PubMed:9554850
PubMed:9705271
PubMed:9315668
Interphase 
telomere 
role in t-loops? 
PubMed:10888888
G2 
PML/ND10 bodies 
co-localisation with TRF1 in late S/G2 
PubMed:10913111
PubMed:15970667
S - interphase 
replication foci 
 
PubMed:1148603
Interphase 
ALT-associated PML body 
in ALT cells 
PubMed:15075340
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
80.6 
5.61 
 
 
708 
Entrez Protein:AAC36249
OMIM:604391
genelynxhs:6226
Uniprot:P49959
PubMed:22863007
80.2 
5.7 
 
 
706 
PubMed:11196167
Entrez Protein:AAB04955
Uniprot:Q61216
 
 
 
 
706 
Uniprot:Q9JIM0
 
 
 
 
700 
Uniprot:Q9IAM7
Annotation
X
Start
End
Domain
Description
13 
249 
metallophosph 
 
Biological Process
X
GO ID
Term
Links
GO:0006281 
DNA repair 
PubMed:11113202
PubMed:14657032
GO:0006281 
DNA repair 
PubMed:15864295
GO:0006261 
DNA-dependent DNA replication 
PubMed:11511367
GO:0006302 
double-strand break repair 
PubMed:11741547
pubmed:21458667
GO:0006974 
response to DNA damage stimulus 
PubMed:15741314
PubMed:14657032
PubMed:15064416
GO:0007003 
telomere binding 
PubMed:10888888
GO:0016446 
somatic hypermutation of antibody genes 
PubMed:16285919
GO:0000723 
telomere maintenance 
pubmed:19633651
GO:0097681 
double-strand break repair via alternative nonhomologous end joining 
pubmed:29929045
Molecular Function
X
GO ID
Term
Links
GO:0004518 
nuclease activity 
PubMed:9705271
GOIDHERE 
3.-5. exonuclease activity 
pubmed:19633651
Other Function
X
Function
Links
AT-like disorder. radiosensitivity and an increased level of spontaneously occurring chromosome aberrations in peripheral blood lymphocytes 
OMIM:604391
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
MRE11 
Saccharomyces cerevisiae 
PubMed:11430828
Entrez Protein:CAA90195
Uniprot:P32829
mre 
Caenorhabditis elegans 
PubMed:11238374
SbcD 
Escherichia coli 
PubMed:12151226
History
X
Created On
Last Changed
2001-04-17 16:23:11 
2006-02-15 09:14:22