Names
Name
Species
Main
BLM 
Homo sapiens 
True 
RECQ2 
 
False 
RECQL3 
 
False 
Keywords
RNA polymerase I, nucleolus, APB, cancer, chromosome instability, genetic disease, helicase, homologous recombination, PML bodies, sister chromatid separation, SUMO, DNA repair, Holliday junction resolvase, meiotic recombination, alt telomere pathway, G-Quadruplex, BTR complex
Location
Location
Species
15q26.1 
Homo sapiens 
Subcellular Localisation
Stage
Description
Details
Links
S - meiosis 
PML/ND10 bodies 
assembles into fraction of PML bodies with rad51 and RP-A 
G2 
PML/ND10 bodies 
assembles into fraction of PML bodies with rad51 and RP-A 
Interphase 
repair foci 
with PML at sites of ssDNA after radiation 
meiosis 
synaptonemal complex 
in prophase, co-localises with RP-A 
Interphase 
telomere 
in ALT cells 
Interphase 
ALT-associated PML body 
in ALT cells 
anaphase - mitosis 
anaphase bridges 
 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Biological Process
GO ID
Term
Links
GO:0006310 
DNA recombination 
GO:0006261 
DNA-dependent DNA replication 
GO:0007004 
telomerase-dependent telomere maintenance 
GO:0000019 
regulation of mitotic recombination 
GO:0000819 
sister chromatid segregation 
GOIDHERE 
telomere maintenance 
GO:0007131 
reciprocal meiotic recombination 
GO:0045943 
positive regulation of transcription from RNA polymerase I promoter 
Molecular Function
GO ID
Term
Links
GO:0003678 
DNA helicase activity 
GO:0048476 
Holliday junction resolvase complex 
GO:0044806 
G-quadruplex DNA unwinding 
Other Function
Function
Links
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
RecQ 
Escherichia coli 
DmBlm 
Drosophila melanogaster 
BLM 
Gallus gallus 
xBlm 
Xenopus laevis 
Sgs1 
Saccharomyces cerevisiae 
Rqh1 
Schizosaccharomyces pombe 
History
Created On
Last Changed
2001-04-23 11:48:00 
2008-01-02 14:45:14