Names
Name
Species
Main
RECQL2 
Homo sapiens 
False 
WRN 
Homo sapiens 
True 
Keywords
cancer, chromosome instability, ds breakage, exonuclease, genetic disease, helicase, DNA replication, heterochromatin, RNA polymerase I, telomere, nucleolus, senescence, G-Quadruplex
Location
Location
Species
8A4 
Mus musculus 
8p12-p11.2 
Homo sapiens 
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
nucleolus 
only in proliferating human cells. Nucleoplasmic in serum starved cell, after ActD, + in the mouse. 
S - meiosis 
repair foci 
with RP-A in hydroxyurea arrested cells 
Interphase 
repair foci 
with RPA and rad51 after DNA damage. Partial co-localisation with PML bodies 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
157.3 
6.1 
 
 
1401 
Annotation
Start
End
Domain
Description
53 
232 
35ExoC 
 
545 
740 
DEAD box 
 
778 
859 
Helicase 
 
1150 
1229 
HRDC 
 
1403 
1406 
NLS 
also nucleolar targetting 
47 
226 
35ExoC 
 
85 
91 
NLS 
 
509 
704 
DEAD box 
 
743 
824 
Helicase 
 
1115 
1194 
HRDC 
 
1336 
1339 
NLS 
 
Biological Process
GO ID
Term
Links
GO:0006281 
DNA repair 
GO:0006261 
DNA-dependent DNA replication 
GO:0006312 
mitotic recombination 
GO:0000723 
telomere maintenance 
GO:0006360 
transcription from Pol I promoter 
GO:1902153 
regulation of response to DNA damage checkpoint signaling 
GO:0070828 
heterochromatin organization 
Molecular Function
GO ID
Term
Links
GO:0008408 
3.-5. exonuclease activity 
GO:0003684 
damaged DNA binding 
GO:0003678 
DNA helicase activity 
GO:0044806 
G-quadruplex DNA unwinding 
Other Function
Function
Links
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
RecQ 
Escherichia coli 
Sgs1 
Saccharomyces cerevisiae 
ffa-1 
Xenopus laevis 
Rqh1 
Schizosaccharomyces pombe 
History
Created On
Last Changed
2001-04-23 13:06:09 
2006-07-13 16:14:51