Names
X
Name
Species
Main
DNA topoisomerase I 
 
False 
TOP1 
Homo sapiens 
False 
topoisomerase I 
Homo sapiens, Mus musculus 
True 
Keywords
X
chromosome scaffold, genome stability, DNA replication, mitotic chromosomes, mRNA splicing, topoisomerase, ribonucleotide excision repair, RER
Location
X
Location
Species
20q12-q13.1 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nucleolus 
In granular component with p14ARF 
PubMed:11314011
PubMed:12429849
Mitosis 
chromosomal 
 
PubMed:15609038
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
90.8 
9.33 
 
 
765 
Entrez Protein:P11387
PubMed:98155246
OMIM:126420
Uniprot:P11387
 
 
 
 
766 
Entrez Protein:NP_033434
Uniprot:Q04750
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006376 
mRNA splice site selection 
PubMed:8609994
pubmed:20862310
GOIDHERE 
maintenance of genome stability 
pubmed:19838172
pubmed:20862310
GO:0048478 
replication fork protection 
pubmed:19838172
GO:0050684 
regulation of mRNA processing 
pubmed: 20862310
GO:1990516 
ribonucleotide excision repair 
pubmed:23375499
Molecular Function
X
GO ID
Term
Links
GO:0003917 
DNA topoisomerase type I activity 
PubMed:98155254
Other Function
X
Function
Links
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
TOP1 
Caenorhabditis elegans 
PubMed:1131887
History
X
Created On
Last Changed
2001-05-02 09:35:41 
2005-01-19 16:40:24