Names
X
Name
Species
Main
HDM2 
Homo sapiens 
False 
MDM2 
Homo sapiens, Mus musculus 
True 
Keywords
X
ATM phosphorylation, ds break repair, Irradiation induced foci, nucleolus, PML bodies, ubiquitin ligase, stem cell, Polycomb
Location
X
Location
Species
12q14.3-q15 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nucleolar 
 
PubMed:11306450
PubMed:15195100
PubMed:16129783
Interphase 
nuclear-cytoplasmic shuttling 
shuttling prevented by p14ARF 
PubMed:11306450
Interphase 
PML/ND10 bodies 
after overexpression of PML 
PubMed:12915590
pubmed:18264029
Interphase 
IR-induced foci 
 
PubMed:15734743
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
55.2 
4.2 
 
 
491 
Entrez Protein:Q00987
PubMed:11313871
OMIM:164785
Uniprot:Q00987
 
 
 
 
489 
Entrez Protein:P23804
Uniprot:P23804
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006302 
double-strand break repair 
PubMed:15734743
GO:0016574 
histone ubiquitination 
PubMed:15546622
GO:0007049 
cell cycle 
PubMed:14707284
PubMed:14704432
GO:0019827 
stem cell maintenance 
pubmed:26748827
GO:0006340 
negative regulation of transcription of homeotic gene (Polycomb group) 
pubmed:26748827
Molecular Function
X
GO ID
Term
Links
GO:0004842 
ubiquitin-protein ligase activity 
PubMed:20187618
Other Function
X
Function
Links
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
MDM2 
Xenopus laevis 
Uniprot:P56273
History
X
Created On
Last Changed
2001-05-02 09:48:35 
2005-05-04 12:57:22