Names
X
Name
Species
Main
DNA (cytosine-5-)-methyltransferase 3a 
Homo sapiens, Mus musculus 
False 
DNMT3a 
Homo sapiens, Mus musculus 
True 
ES485 
Mus musculus 
False 
Keywords
X
growth, dna methylase, gene trap, histone deacetylase complex, histone methylation, PWWP domain, mitotic chromosomes, repression complex, transcription repression, methyl-lysine binding, transcription elongation, H3K36me3 binding, genetic disease, acute leukemia, cancer, differentiation, mutated in cancer, AML, Tatton-Brown-Rahman syndrome, overgrowth
Location
X
Location
Species
12 
Mus musculus 
2p23 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
heterochromatin 
 
PubMed:11427539
PubMed:15456878
Interphase 
nuclear diffuse 
gene -trap is nuclear diffuse. Dnmt3a2 isoform is also diffuse over chromatin 
PubMed:12138111
Mitosis 
chromosomal 
depends on PWWP domain 
PubMed:14998998
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
101.9 
6.19 
 
 
912 
Entrez Protein:NP_072046
Uniprot:Q9Y6K1
PubMed:21067377
PubMed:21415852
PubMed:24614070
PubMed:24656771
101.7 
6.27 
 
 
908 
Entrez Protein:NP_031898
Uniprot:O88508
Annotation
X
Start
End
Domain
Description
1 
209 
gene trap insertion 
 
51 
57 
NLS 
 
200 
203 
NLS 
 
290 
348 
PWWP 
 
448 
455 
OB 
 
452 
459 
NLS 
 
627 
633 
NLS 
 
634 
907 
DNA methylase 
 
48 
53 
NLS 
 
196 
199 
NLS 
 
286 
344 
PWWP 
 
448 
455 
NLS 
 
623 
629 
NLS 
 
630 
903 
DNA methylase 
 
Biological Process
X
GO ID
Term
Links
GO:0006338 
chromatin remodeling 
PubMed:12711675
GO:0006306 
DNA methylation 
PubMed:10555141
PubMed Central:10805783
GO:0006346 
methylation-dependent chromatin silencing 
PubMed:11350943
pubmed: 22584578
GO:0045944 
positive regulation of transcription from RNA polymerase II promoter 
pubmed:20651149
GO:0048863 
stem cell differentiation 
pubmed:22138693
Molecular Function
X
GO ID
Term
Links
GO:0003886 
DNA (cytosine-5-)-methyltransferase activity 
PubMed:10555141
PubMed:11399089
PubMed Central:10805783
GO:0035064 
methylated histone residue binding 
pubmed:20547484
Other Function
X
Function
Links
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
History
X
Created On
Last Changed
2001-07-05 16:20:38 
2004-12-04 20:37:52