Names
X
Name
Species
Main
HIF-1 alpha 
Homo sapiens, Mus musculus 
True 
MOP1 
 
False 
bHLHe78 
 
false 
PASD8 
 
false 
HIF-1A 
 
false 
HIF1 alpha 
 
false 
HIF1A 
 
false 
Keywords
X
nucleolus, hydroxyproline, transcription factor, ubiquitin, HLH, pas domain, hypoxia, sumoylated, adipogenesis, vascular development
Location
X
Location
Species
14q23.2 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nuclear diffuse 
Heterodimer with HIF1-beta. 
Interphase 
nucleolus 
sequestered to nucleolus by p14ARF 
PubMed:11382768
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
95.5 
5.17 
 
 
850 
Entrez Protein:NP_001230013
PubMed:11313887
Uniprot:Q16665
91.9 
5.17 
 
 
822 
Entrez Protein:Q61221
Uniprot:Q61221
Annotation
X
Start
End
Domain
Description
17 
33 
NLS BP 
 
23 
78 
HLH 
 
87 
153 
PAS 
 
230 
296 
PAS 
 
302 
345 
PAC 
 
718 
721 
NLS 
 
17 
33 
NLS BP 
 
23 
78 
HLH 
 
87 
153 
PAS 
 
154 
160 
NLS 
 
230 
296 
PAS 
 
302 
345 
PAC 
 
714 
717 
NLS 
 
Biological Process
X
GO ID
Term
Links
GO:0006357 
regulation of transcription from Pol II promoter 
PubMed Central:10758161
GO:0032364 
oxygen homeostasis 
pubmed:7539918
GO:0060612 
adipose tissue development 
pubmed:11879638
Molecular Function
X
GO ID
Term
Links
GO:0003677 
DNA binding 
PubMed Central:10758161
GO:0003704 
specific RNA polymerase II transcription factor activity 
PubMed Central:10758161
Other Function
X
Function
Links
angiogenesis, erythropoiesis and glycolysis 
PubMed Central:10758161
induction of oxygen regulated genes. Heterodimer with HIF1-beta. 
PubMed Central:10758161
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
HIF-1 alpha 
Caenorhabditis elegans 
PubMed:11427734
History
X
Created On
Last Changed
2001-07-12 11:03:19 
2004-12-02 15:29:43