Names
X
Name
Species
Main
HIF-1 alpha 
Homo sapiens, Mus musculus 
True 
MOP1 
 
False 
bHLHe78 
 
false 
PASD8 
 
false 
HIF-1A 
 
false 
HIF1 alpha 
 
false 
HIF1A 
 
false 
Keywords
X
nucleolus, hydroxyproline, transcription factor, ubiquitin, HLH, pas domain, hypoxia, sumoylated, adipogenesis, vascular development
Location
X
Location
Species
14q23.2 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nuclear diffuse 
Heterodimer with HIF1-beta. 
Interphase 
nucleolus 
sequestered to nucleolus by p14ARF 
PubMed:11382768
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
95.5 
5.17 
 
 
850 
Entrez Protein:NP_001230013
PubMed:11313887
Uniprot:Q16665
91.9 
5.17 
 
 
822 
Entrez Protein:Q61221
Uniprot:Q61221
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006357 
regulation of transcription from Pol II promoter 
PubMed Central:10758161
GO:0032364 
oxygen homeostasis 
pubmed:7539918
GO:0060612 
adipose tissue development 
pubmed:11879638
Molecular Function
X
GO ID
Term
Links
GO:0003677 
DNA binding 
PubMed Central:10758161
GO:0003704 
specific RNA polymerase II transcription factor activity 
PubMed Central:10758161
Other Function
X
Function
Links
angiogenesis, erythropoiesis and glycolysis 
PubMed Central:10758161
induction of oxygen regulated genes. Heterodimer with HIF1-beta. 
PubMed Central:10758161
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
HIF-1 alpha 
Caenorhabditis elegans 
PubMed:11427734
History
X
Created On
Last Changed
2001-07-12 11:03:19 
2004-12-02 15:29:43