Names
X
Name
Species
Main
EPAS-1 
Homo sapiens, Mus musculus 
True 
HIF-2 alpha 
 
False 
HRF 
Homo sapiens, Mus musculus 
False 
MOP2 
Homo sapiens, Mus musculus 
False 
bHLHe73 
 
false 
PASD2 
 
false 
HIF2A 
 
false 
Keywords
X
predominantly endothelial cells, transcription factor, hypoxia, HLH, pas domain, genetic disease
Location
X
Location
Species
2p21-p16 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nuclear diffuse 
 
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
96.4 
6.19 
 
 
870 
PubMed:23361906
Entrez Protein:NP_001421
Uniprot:Q99814
 
 
 
 
874 
Entrez Protein:P97481
Uniprot:P97481
Annotation
X
Start
End
Domain
Description
14 
30 
NLS BP 
 
20 
75 
HLH 
 
86 
152 
PAS 
 
232 
298 
PAS 
 
304 
347 
PAC 
 
Biological Process
X
GO ID
Term
Links
GO:0006357 
regulation of transcription from Pol II promoter 
PubMed:97152468
GO:0032364 
oxygen homeostasis 
pubmed:23361906
Molecular Function
X
GO ID
Term
Links
GO:0003677 
DNA binding 
PubMed:97152468
GO:0003704 
specific RNA polymerase II transcription factor activity 
PubMed:97152468
Other Function
X
Function
Links
activates transcription of the endothelial tyrosine kinase gene Tie-2 
remodeling of the primary vascular network into a mature hierarchy pattern 
PubMed Central:10880563
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
History
X
Created On
Last Changed
2001-07-12 12:53:41 
2002-04-12 13:55:26