Names
X
Name
Species
Main
Top IIIa 
Homo sapiens 
False 
Topo IIIalpha 
Homo sapiens, Mus musculus 
False 
topoisomerase III alpha 
Homo sapiens, Mus musculus 
True 
TP3A 
Homo sapiens, Mus musculus 
False 
Top3A 
 
false 
Keywords
X
homologous recombination, Holliday junction resolvase, PML bodies, topoisomerase, zinc finger C2HC, meiotic recombination, alt telomere pathway, BTR complex
Location
X
Location
Species
17p12-p11.2 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
PML/ND10 bodies 
co-localisation and interaction with BLM 
PubMed:10728666
PubMed:16199871
Interphase 
mitochondria 
 
PubMed:12209014
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
112.4 
8.69 
 
 
1001 
OMIM:601243
Entrez Protein:NP_004609
112.4 
8.73 
 
 
1003 
Entrez Protein:NP_033436
Annotation
X
Start
End
Domain
Description
35 
169 
TOPRIM 
 
172 
269 
TOP1Bc 
 
286 
289 
NLS 
 
315 
569 
TOP1Ac 
 
656 
672 
NLS BP 
 
965 
968 
NLS 
 
979 
983 
NLS 
 
983 
999 
C2HC Zn finger 
 
35 
169 
TOPRIM 
 
172 
269 
TOP1Bc 
 
315 
569 
TOP1Ac 
 
656 
672 
NLS BP 
 
967 
970 
NLS 
 
981 
985 
NLS 
 
985 
1001 
C2HC Zn finger 
 
Biological Process
X
GO ID
Term
Links
GO:0006310 
DNA recombination 
PubMed:10728666
GO:0000019 
regulation of mitotic recombination 
PubMed:14685245
pubmed:25699707
GO:0071139 
resolution of recombination intermediates 
pubmed:16595695
GO:0000722 
telomere maintenance via recombination 
pubmed: 28877996
pubmed:31138797
Molecular Function
X
GO ID
Term
Links
GO:0003916 
DNA topoisomerase activity 
PubMed:10728666
GO:0048476 
Holliday junction resolvase complex 
pubmed:14685245
pubmed:17728255
Other Function
X
Function
Links
homozygous lethal 
PubMed: 9448276
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
TP3A 
Drosophila melanogaster 
Entrez Protein:Q9NG98
History
+