Names
Name
Species
Main
ATR 
Homo sapiens 
True 
FRP1 
Homo sapiens 
False 
FCTCS 
 
false 
MEC1 
 
false 
SCKL 
 
false 
SCKL1 
 
false 
Keywords
ATM, chromosome breakage, chromosome instability, DNA damage, ds break repair, fat domain, genetic disease, HEAT, Irradiation induced foci, meiotic chromosomes, meiotic prophase, meiotic recombination, PI3kinase, PML bodies, serine threonine kinase, tpr, Seckel syndrome, microcephaly, photoreceptor function, heat repeats, nuclear periphery, meiotic prophase
Location
Location
Species
3q22-q24 
Homo sapiens 
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
BRCA1 nuclear dots 
co-localisation with brca1 after damage 
Interphase 
replication foci 
co-localisation with stalled replication forks 
Interphase 
nucleolus 
 
prophase - meiosis 
axial elements of synaptonemal complex 
unsynapsed elements 
Interphase 
PML/ND10 bodies 
 
pachytene 
XY body 
 
Interphase 
cilia 
in photoreceptors 
S phase 
nuclear periphery 
 
prophase - mitosis 
nuclear periphery 
 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Start
End
Domain
Description
429 
446 
NLS BP 
 
430 
447 
NLS BP 
 
525 
528 
NLS 
 
805 
839 
heat 
 
1119 
1125 
UME 
 
1329 
1365 
heat 
 
1640 
2185 
fat 
 
1699 
1732 
TPR 
 
2308 
2311 
NLS 
 
2323 
2633 
PI3Kc 
 
2612 
2644 
fatc 
 
Biological Process
GO ID
Term
Links
GO:0000077 
DNA damage checkpoint 
GO:0006975 
DNA damage induced protein phosphorylation 
GO:0016446 
somatic hypermutation of antibody genes 
GO:0016447 
somatic recombination of antibody genes 
GO:0007128 
meiotic prophase I 
Molecular Function
GO ID
Term
Links
GO:0003684 
damaged DNA binding 
GO:0004674 
protein serine/threonine kinase activity 
Other Function
Function
Links
caspase-independent chromosome breaks are observed in ATR(-/-) cells 
embryonic lethal E8.5 
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
Rad3 
Schizosaccharomyces pombe 
Esr1 
Saccharomyces cerevisiae 
Mec1 
Saccharomyces cerevisiae 
History