Names
X
Name
Species
Main
ERCC1 
Homo sapiens, Mus musculus 
True 
COFS4 
 
false 
RAD10 
 
false 
UV20 
 
false 
Keywords
X
chromosome instability, endonuclease, HHH, nucleotide excision repair, photosensitivity, structure-specific nuclease, interstrand crosslinks, DNA repair
Location
X
Location
Species
19q13.32 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nuclear diffuse 
immobilised for 4 mins after induction of DNA damage 
PubMed:10320375
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
35.4 
5.9 
 
 
323 
Uniprot:P07992
Entrez Protein:NP_973730
 
 
 
 
298 
Entrez Protein:P07903
Uniprot:P07903
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006310 
DNA recombination 
PubMed:11707424
GO:0006281 
DNA repair 
PubMed:10320375
GO:0006289 
nucleotide-excision repair 
PubMed:11160918
GO:0036297 
interstrand cross-link repair 
pubmed:21896658
Molecular Function
X
GO ID
Term
Links
GO:0003686 
DNA repair enzyme 
PubMed:NA11160918
GO:0003685 
DNA repair protein 
PubMed:11160918
GO:0004519 
endonuclease activity 
PubMed:11160918
Other Function
X
Function
Links
maintenance of genomic stability 
PubMed:9427687
PubMed:9197240
structure-specific nuclease with two subunits, ERCC1 and XPF. The enzyme cuts DNA at junctions where a single strand moves 5. to 3. away from a branch point with duplex DNA 
PubMed:11160918
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
rad10 
Saccharomyces cerevisiae 
Uniprot:P06838
swi10 
Schizosaccharomyces pombe 
Uniprot:Q06182
History
X
Created On
Last Changed
2001-07-18 12:54:59 
2002-04-12 13:57:25