Names
Name
Species
Main
ERCC1 
Homo sapiens, Mus musculus 
True 
COFS4 
 
false 
RAD10 
 
false 
UV20 
 
false 
Keywords
chromosome instability, endonuclease, HHH, nucleotide excision repair, photosensitivity, structure-specific nuclease, interstrand crosslinks, DNA repair
Location
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
nuclear diffuse 
immobilised for 4 mins after induction of DNA damage 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Start
End
Domain
Description
16 
23 
NLS 
 
269 
288 
helix hairpin helix (HHH) 
 
279 
285 
NLS 
 
Biological Process
GO ID
Term
Links
GO:0006310 
DNA recombination 
GO:0006281 
DNA repair 
GO:0006289 
nucleotide-excision repair 
GO:0036297 
interstrand cross-link repair 
Molecular Function
GO ID
Term
Links
GO:0003686 
DNA repair enzyme 
GO:0003685 
DNA repair protein 
GO:0004519 
endonuclease activity 
Other Function
Function
Links
maintenance of genomic stability 
structure-specific nuclease with two subunits, ERCC1 and XPF. The enzyme cuts DNA at junctions where a single strand moves 5. to 3. away from a branch point with duplex DNA 
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
rad10 
Saccharomyces cerevisiae 
swi10 
Schizosaccharomyces pombe 
History
Created On
Last Changed
2001-07-18 12:54:59 
2002-04-12 13:57:25