Names
X
Name
Species
Main
ERCC2 
 
False 
XPD 
Homo sapiens 
True 
Keywords
X
ataxia, basal transcription factor, cancer, genetic disease, helicase, mental retardation, nucleotide excision repair, photosensitivity, TFIIH, transcription_coupled repair, XP CS and TTD, iron-sulfur-containing DNA helicase
Location
X
Location
Species
19q13.2-q13.3 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nuclear+cytoplasmic 
 
PubMed:11266560
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
86.9 
6.72 
 
 
760 
Entrez Protein:NP_000391
Uniprot:P18074
86.8 
6.47 
 
 
760 
Entrez Protein:O08811
Annotation
X
Start
End
Domain
Description
8 
280 
DEAD box 
 
542 
686 
Helicase 
 
8 
280 
DEAD box 
 
542 
686 
Helicase 
 
Biological Process
X
GO ID
Term
Links
GO:0006289 
nucleotide-excision repair 
PubMed:11242112
PubMed:10673506
pubmed:25268380
GO:0006283 
transcription-coupled nucleotide-excision repair 
PubMed:12732143
GO:0000074 
regulation of cell cycle 
PubMed:12853965
GO:0006352 
transcription initiation 
PubMed:11239393
PubMed:11242112
Molecular Function
X
GO ID
Term
Links
GO:0003678 
DNA helicase activity 
PubMed:11141066
GO:0016251 
general RNA polymerase II transcription factor activity 
PubMed:8692841
Other Function
X
Function
Links
Embryonic lethal D7.5 
PubMed:98086032
XP, CS and TTD 
OMIM:126340
OMIM:278730
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
Rad3 
Saccharomyces cerevisiae 
PubMed:90228341
OMIM:126340
Rad15 
Schizosaccharomyces pombe 
OMIM:126340
DmXPD 
Drosophila melanogaster 
PubMed Central:10198066
History
X
Created On
Last Changed
2001-07-19 12:05:37 
2004-12-04 20:23:13