Names
X
Name
Species
Main
ERCC5 
 
False 
XPG 
Homo sapiens, Mus musculus 
True 
Keywords
X
ataxia, endonuclease, genetic disease, HHH, nucleotide excision repair, photosensitivity, TFIIH, transcription_coupled repair, XERODERMA PIGMENTOSUM_G_COCKAYNE SYNDROME COMPLEX, structure-specific nuclease
Location
X
Location
Species
13q33 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nuclear dots 
No of XPG foci decreased 2 h after UV irradiation of skin fibroblasts. Within 8h in foci again 
PubMed:8710877
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
133.3 
5.19 
 
 
1186 
Entrez Protein:NP_000114
OMIM:133530
Uniprot:P28715
130.9 
5.24 
 
 
1170 
Entrez Protein:P35689
Annotation
X
Start
End
Domain
Description
1 
98 
XPGN 
 
213 
216 
NLS 
 
777 
846 
XPGI 
 
848 
881 
helix hairpin helix (HHH) 
 
1057 
1076 
NLS BP 
 
1182 
1185 
NLS 
 
1 
98 
XPGN 
 
213 
216 
NLS 
 
776 
845 
XPGI 
 
847 
880 
helix hairpin helix (HHH) 
 
902 
918 
NLS 
 
1048 
1065 
NLS BP 
 
1150 
1156 
NLS 
 
1163 
1168 
NLS 
 
Biological Process
X
GO ID
Term
Links
GO:0006289 
nucleotide-excision repair 
PubMed:11259578
OMIM:133530
GO:0006283 
transcription-coupled nucleotide-excision repair 
PubMed:10786832
PubMed:9096355
OMIM:133530
Molecular Function
X
GO ID
Term
Links
GO:0004519 
endonuclease activity 
PubMed:14993263
PubMed:8078765
Other Function
X
Function
Links
Purkinje cell maintenance 
PubMed:11340641
XERODERMA PIGMENTOSUM-G/COCKAYNE SYNDROME COMPLEX 
OMIM:133530
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
RAD2 
Saccharomyces cerevisiae 
Entrez Protein:NP_011774
UVH3 
Arabidopsis 
PubMed:11439121
Mus201 
Drosophila melanogaster 
PubMed:11104904
History
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