Names
Keywords
histone deacetylase, transcription repression, Class II HDAC
Location
Location
Species
12q13.1 
Homo sapiens 
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
nuclear-cytoplasmic shuttling 
Serum withdrawal leads to the translocation of HDAC7 from the nucleus into the cytoplasm. 
Interphase 
nuclear 
and in mitochondrial inner membrane space (IMS). Relocates to cytoplasm on initiation of apoptosis 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
103 
7.24 
 
 
952 
Annotation
Start
End
Domain
Description
151 
167 
NLS BP 
 
183 
190 
NLS 
 
518 
865 
HDAC 
class II 
174 
190 
NLS BP 
 
206 
213 
NLS 
 
505 
852 
HDAC 
class II 
Biological Process
GO ID
Term
Links
GO:0006338 
chromatin remodeling 
GO:0000122 
negative regulation of transcription from Pol II promoter 
GO:0033233 
regulation of protein sumoylation 
GO:0030578 
PML body organization 
Molecular Function
GO ID
Term
Links
GO:0004407 
histone deacetylase activity 
Other Function
Function
Links
muscle differentiation. Prevents MEF2 gene activation by binding. Sequestered to cytoplasm upon induction of differentiation. 
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
HDA1 
Saccharomyces cerevisiae 
History
Created On
Last Changed
2001-08-23 14:05:53 
2004-10-12 14:10:15