Names
Name
Species
Main
nsd1 
Homo sapiens, Mus musculus 
True 
Keywords
acute leukemia, AML, cancer, genetic disease, histone methylase, set domain, leukaemia, leukaemia_associated translocation, mental retardation, nuclear receptor interacting, PWWP domain, PHD finger, transcription co activator, transcription corepressor, meth, H3K36me3 binding, H3K36 methylation, DNA methylation, Sotos, overgrowth
Location
Location
Species
5q35.3 
Homo sapiens 
Subcellular Localisation
Stage
Description
Details
Links
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
284.1 
8.24 
 
 
2588 
Annotation
Start
End
Domain
Description
409 
425 
NLS BP 
 
1053 
1073 
NLS BP 
 
1191 
1197 
NLS 
 
1364 
1385 
NLS BP 
 
1442 
1484 
PHD finger 
 
1489 
1536 
PHD finger 
 
1537 
1590 
PHD finger 
 
1606 
1646 
PHD finger 
 
1651 
1713 
PWWP 
 
1787 
1838 
aws 
 
1839 
1962 
SET 
 
1963 
1979 
post SET 
 
2017 
2060 
PHD finger 
 
409 
425 
NLS BP 
 
948 
951 
NLS 
 
1055 
1071 
NLS BP 
 
1192 
1198 
NLS 
 
1365 
1386 
NLS BP 
 
1443 
1485 
PHD finger 
 
1490 
1537 
PHD finger 
 
1538 
1591 
PHD finger 
 
1607 
1647 
PHD finger 
 
1652 
1714 
PWWP 
 
1788 
1839 
aws 
 
1840 
1963 
SET 
 
1964 
1980 
post SET 
 
1998 
2007 
NLS 
 
2018 
2061 
PHD finger 
 
Biological Process
GO ID
Term
Links
GO:0016571 
histone methylation 
GO:0006357 
regulation of transcription from Pol II promoter 
GO:0044030 
regulation of DNA methylation 
Molecular Function
GO ID
Term
Links
GO:0046975 
histone lysine N-methyltransferase activity (H3-K36 specific) 
GO:0018024 
histone-lysine N-methyltransferase activity 
GO:0035064 
methylated histone residue binding 
Other Function
Function
Links
essential for early post-implantation development 
haploinsufficiency in Sotos syndrome 
Expression
Related Genes
Name
Species
Links
MES4 
Caenorhabditis elegans 
Set2 
Saccharomyces cerevisiae 
History
Created On
Last Changed
2001-08-29 14:06:40 
2005-08-18 13:24:37