Names
Keywords
ATPase, centromere protein, chromosome scaffold, chromosome segregation, meiotic chromosomes, mitotic centromere, mitotic chromosomes, nuclear mRNA splicing via spliceosome, topoisomerase, transcription elongation, replication fork reversal, stalled replication fork
Location
Location
Species
17q21-q22 
Homo sapiens 
Subcellular Localisation
Stage
Description
Details
Links
prophase - meiosis 
heterochromatin 
centromeric heterochromatin 
G2 
centromere 
centromeric heterochromatin concentration 
metaphase - mitosis 
centromere 
until mid anaphase 
prometapha 
chromosome core 
 
S - interphase 
heterochromatin 
in late S 
Interphase 
splicing speckles 
catalytically inactive form 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Start
End
Domain
Description
76 
225 
HATPase c 
 
80 
670 
TOP2c 
 
603 
609 
NLS 
 
632 
635 
NLS 
 
661 
677 
NLS BP 
 
693 
1169 
TOP4c 
 
727 
743 
NLS BP 
 
1068 
1071 
NLS 
 
1270 
1291 
NLS BP 
 
1463 
1468 
NLS 
 
Biological Process
GO ID
Term
Links
GO:0006915 
apoptosis 
GO:0007002 
centromere binding 
GO:0007076 
mitotic chromosome condensation 
GO:0000398 
nuclear mRNA splicing, via spliceosome 
GO:0006350 
transcription 
GO:0000070 
mitotic sister chromatid segregation 
GO:0070683 
decatenation checkpoint 
GO:0071932 
replication fork reversal 
Molecular Function
GO ID
Term
Links
GO:0004002 
ATPase activity 
GO:0003918 
DNA topoisomerase (ATP-hydrolyzing) activity 
Other Function
Function
Links
Expression
Experiment
Detail
Links
Immunohistochemistry 
proliferating cells 
Related Genes
Name
Species
Links
DNA topoisomerase II alpha 
Gallus gallus 
DNA topoisomerase II 
Drosophila melanogaster 
DNA topoisomerase II 
Schizosaccharomyces pombe 
History
Created On
Last Changed
2001-09-19 10:06:29 
2004-12-02 15:09:52