Names
X
Name
Species
Main
IK1 
 
False 
Ikaros 
Gallus gallus, Homo sapiens, Mus musculus 
True 
LYF-1 
 
False 
ZNFN1A1 
 
False 
IKZF1 
 
false 
Keywords
X
acute lymphoblastic leukemia ALL, cancer, chromatin remodelling, leukaemia, Lymphoid restricted. But Ikaros is present in most hematopoietic cells, lymphoma, lymphoma_associated translocation, nurd, quiescence, swi_snf, transcription repression, zinc finger C2_H2
Location
X
Location
Species
7p12 
Homo sapiens 
11 
Mus musculus 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
heterochromatin 
in pre-B lymphocytes 
PubMed:10970879
PubMed:9435248
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
57.5 
6.12 
 
 
519 
Entrez Protein:Q13422
OMIM:603023
Uniprot:Q13422
PubMed:23233609
 
 
 
 
517 
Uniprot:Q03267
 
 
 
 
518 
Entrez Protein:O42410
Uniprot:O42410
Annotation
X
Start
End
Domain
Description
117 
139 
ZnF_C2H2 
 
145 
167 
ZnF_C2H2 
 
173 
195 
ZnF_C2H2 
 
201 
224 
ZnF_C2H2 
 
462 
484 
ZnF_C2H2 
 
490 
514 
ZnF_C2H2 
 
Biological Process
X
GO ID
Term
Links
GO:0006338 
chromatin remodeling 
PubMed:11003653
PubMed:11799125
GO:0000122 
negative regulation of transcription from Pol II promoter 
PubMed:11387214
PubMed:11459831
GO:0000074 
regulation of cell cycle 
PubMed:15713624
Molecular Function
X
GO ID
Term
Links
GO:0003677 
DNA binding 
PubMed:10970879
Other Function
X
Function
Links
Fusion of the Ikaros and BCL6 genes in t(3;7)(q27;p12) translocations in DLBL. 
PubMed:10753856
Mice homozygous for a germline mutation in the Ikaros DNA-binding domain lack not only T and B lymphocytes and natural killer cells, but also their earliest defined progenitors. Also haemopoietic defects and dleayed globin switching 
PubMed: 7923373
PubMed:11805317
mice that express only non-DNA-binding dominant-negative 'leukemogenic' Ikaros isoforms lacking critical N-terminal zinc fingers develop an aggressive form of lymphoblastic leukemia 
PubMed:10945610
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
History
X
Created On
Last Changed
2001-09-21 16:38:08 
2005-08-22 14:59:40