Names
Name
Species
Main
AML1 
Homo sapiens 
True 
CBF-ALPHA B 
 
False 
CBFA2 
 
False 
PEBP2 alpha 
 
False 
RUNX1 
 
False 
Keywords
acute leukemia, AML, cml, haemopoiesis, heterodimer, PRC1, leukaemia, leukaemia_associated translocation, PML bodies, transcription factor, osteogenesis, Polycomb, ALL
Location
Location
Species
21q22.3 
Homo sapiens 
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
PML/ND10 bodies 
 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Start
End
Domain
Description
42 
214 
runt 
 
176 
182 
NLS 
 
Biological Process
GO ID
Term
Links
GO:0006357 
regulation of transcription from Pol II promoter 
GO:0000122 
negative regulation of transcription from RNA polymerase II promoter 
GO:0001649 
osteoblast differentiation 
Molecular Function
GO ID
Term
Links
GO:0003677 
DNA binding 
GO:0003704 
specific RNA polymerase II transcription factor activity 
Other Function
Function
Links
aml1-regulated target genes are essential for definitive hematopoiesis of all lineages. 
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
runt 
Drosophila melanogaster 
History
Created On
Last Changed
2001-10-08 10:38:38 
2004-12-20 15:39:28