Names
X
Name
Species
Main
ESET 
Mus musculus 
False 
H3-K9-HMTase 4 
 
False 
KIAA0067 
Homo sapiens 
False 
SETDB1 
Homo sapiens, Mus musculus 
True 
KMT1E 
 
false 
Keywords
X
H3K9 methylation, chromatin remodelling, histone deacetylase complex, histone methylase, Sin3, proviral silencing, pluripotency, PML bodies, meiotic prophase, meiotic gene silencing
Location
X
Location
Species
1q21.2 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
PML/ND10 bodies 
 
pubmed:19811652
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
143.2 
5.74 
 
 
1291 
Entrez Protein:NP_036564
OMIM:604396
Uniprot:Q15047
144.5 
5.71 
180 
 
1307 
Entrez Protein:NP_061365
Uniprot:O88974
Annotation
X
Start
End
Domain
Description
226 
232 
NLS 
 
256 
318 
tudor 
 
346 
401 
tudor 
 
597 
672 
MBD 
 
679 
786 
preSET 
 
802 
1272 
SET 
 
1275 
1291 
post SET 
 
256 
318 
tudor 
 
346 
401 
tudor 
 
614 
689 
MBD 
 
696 
803 
preSET 
 
820 
1228 
SET 
 
1291 
1307 
post SET 
 
Biological Process
X
GO ID
Term
Links
GO:0006342 
chromatin silencing 
PubMed:12398767
PubMed:11959841
pubmed:19884255
pubmed:20164836
pubmed:21427230
GO:0016571 
histone methylation 
PubMed:11791185
pubmed:19811652
GO:0000122 
negative regulation of transcription from RNA polymerase II promoter 
pubmed:19884257
pubmed:19811652
GO:0019827 
stem cell maintenance 
pubmed:19884257
pubmed: 20014010
pubmed:19811652
GO:0007128 
meiotic prophase I 
pubmed:30393076
Molecular Function
X
GO ID
Term
Links
GO:0046974 
histone lysine N-methyltransferase activity (H3-K9 specific) 
PubMed:11791185
pubmed:19811652
Other Function
X
Function
Links
peri-implantation lethality between 3.5 and 5.5 dpc. No Eset(-/-) ES cell lines 
PubMed:14993285
Expression
X
Experiment
Detail
Links
Northern 
ubiquitous 
In situ 
zygotic Eset expression begins at the blastocyst stage and is ubiquitous during postimplantation mouse development 
PubMed:14993285
Related Genes
X
Name
Species
Links
YNCA 
Caenorhabditis elegans 
Su(var)3-9 
Drosophila melanogaster 
History
X
Created On
Last Changed
2002-01-17 12:45:31 
2005-08-18 13:20:20