Names
Keywords
checkpoint, DNA damage, microcephaly, homologous recombination, transcription repression, ds break repair, nuclease, nhej, genetic disease, interstrand crosslinks, Seckel syndrome, alternative end-joining, R-loops, end resection
Location
Location
Species
18q11.2 
Homo sapiens 
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
nuclear 
some in complex with brca1 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Start
End
Domain
Description
353 
359 
NLS 
 
446 
449 
NLS 
 
874 
884 
NLS 
 
Biological Process
GO ID
Term
Links
GO:0000122 
negative regulation of transcription from Pol II promoter 
GOIDHERE 
DNA damage response, signal transduction 
GO:0000077 
DNA damage checkpoint 
GO:0000724 
double-strand break repair via homologous recombination 
GO:0006303 
double-strand break repair via nonhomologous end joining 
GO:0006281 
DNA repair 
GO:0097681 
double-strand break repair via alternative nonhomologous end joining 
GO:0004523 
RNA-DNA hybrid ribonuclease activity 
Molecular Function
GO ID
Term
Links
GOIDHERE 
embryonic lethality 
Other Function
Function
Links
embryonic lethality 
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
Sae2 
Saccharomyces cerevisiae 
Ctp1 
Schizosaccharomyces pombe 
History
Created On
Last Changed
2002-04-25 12:58:02 
2002-04-25 13:05:36