Names
X
Name
Species
Main
PU.1 
Homo sapiens, Mus musculus 
True 
SFPI-1 
 
False 
SFPI1 
 
False 
SPI1 
 
False 
Keywords
X
myeloid differentiation, acetylation, haemopoiesis, enhancer binding, oncoprotein, ets domain, transcription factor, pioneer factor
Location
X
Location
Species
11p11.2 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nuclear 
 
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
30.4 
6.2 
 
 
264 
Entrez Protein:P17947
OMIM:165170
Uniprot:P17947
 
 
 
 
266 
Entrez Protein:P17433
Uniprot:P17433
Annotation
X
Start
End
Domain
Description
163 
251 
ets 
 
Biological Process
X
GO ID
Term
Links
GO:0006338 
chromatin remodeling 
PubMed:11997509
GO:0043011 
myeloid dendritic cell differentiation 
pubmed:20510866
GO:0006955 
immune response 
pubmed:20431622
GO:0030099 
myeloid cell differentiation 
pubmed:19956253
Molecular Function
X
GO ID
Term
Links
GO:0003704 
specific RNA polymerase II transcription factor activity 
PubMed:15533720
PubMed:9211934
GOIDHERE 
RNA polymerase II transcription factor activity, enhancer binding 
pubmed:20525788
pubmed:20516218
Other Function
X
Function
Links
binds in vivo to PuRS elements from the genes expressed in myeloid cells 
PubMed:15533720
development of both osteoclasts and macrophages arrested. -/- mice born alive but die of septicemia within 24 to 48 hours 
PubMed:9052784
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
History
X
Created On
Last Changed
2002-05-23 09:59:09 
2004-11-12 17:19:16