Names
Name
Species
Main
SIR2 ALPHA SIRTUIN TYPE 1 
 
False 
SIR2L1 
 
False 
SIRT1 
Homo sapiens 
True 
sirtuin 1 
 
False 
SIRTUIN TYPE 1 
 
False 
Keywords
Class III HDAC, heterochromatin, deacetylase complex, histone deacetylase complex, PML bodies, transcription repression, H3K9 methylation
Location
Location
Species
10q22.2 
Homo sapiens 
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
PML/ND10 bodies 
together with p53, when PML is overexpressed 
Interphase 
nuclear-cytoplasmic shuttling 
 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Start
End
Domain
Description
32 
39 
NLS 
 
231 
238 
NLS 
 
261 
447 
sir2 
 
Biological Process
GO ID
Term
Links
GO:0006338 
chromatin remodeling 
GO:0000122 
negative regulation of transcription from Pol II promoter 
GO:0006357 
regulation of transcription from Pol II promoter 
GO:0031507 
heterochromatin formation 
GO:0051567 
histone H3-K9 methylation 
Molecular Function
GO ID
Term
Links
GO:0017136 
NAD-dependent histone deacetylase activity 
Other Function
Function
Links
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. 
Expression
Related Genes
Name
Species
Links
sir2 
Saccharomyces cerevisiae 
History
Created On
Last Changed
2002-05-28 12:24:34 
2007-09-19 14:54:35