Names
Name
Species
Main
DOT1L 
Homo sapiens, Mus musculus 
True 
DOTL 
 
False 
H3-K79-HMTase 
 
False 
KMT4 
 
false 
Keywords
histone methylase, heterochromatin, telomere, leukaemia, leukaemia_associated translocation, reprogramming, H3K79 methylation, dna damage response, transcriptional restart after DNA damage, ubiquitin binding, ubiquitinated histone binding
Location
Subcellular Localisation
Stage
Description
Details
Links
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Start
End
Domain
Description
395 
417 
NLS BP 
 
422 
428 
NLS 
 
1088 
1091 
NLS 
 
1105 
1111 
NLS 
 
1164 
1170 
NLS 
 
Biological Process
GO ID
Term
Links
GO:0016571 
histone methylation 
GO:0031151 
histone methyltransferase activity (H3-K79 specific) 
GO:0000723 
telomere maintenance 
GO:0070829 
heterochromatin maintenance 
GO:0045944 
positive regulation of transcription from RNA polymerase II promoter 
GO:0007067 
mitosis 
GO:0048863 
stem cell differentiation 
GO:0034984 
cellular response to DNA damage stimulus 
Molecular Function
GO ID
Term
Links
GO:0018024 
histone-lysine N-methyltransferase activity 
GO:0031151 
histone methyltransferase activity (H3-K79 specific) 
GO:0043130 
ubiquitin binding 
GO:0061649 
ubiquitinated histone binding 
Other Function
Function
Links
embryonic lethality E9.5 
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
Dot1 
Saccharomyces cerevisiae 
History
Created On
Last Changed
2003-02-28 09:22:01 
2005-01-21 13:49:31