Names
X
Name
Species
Main
UTX 
Homo sapiens 
True 
KDM6A 
 
false 
Keywords
X
cancer, histone demethylation, histone demethylase, genetic disease, jumonji domain, tpr, mll3/4 complex, H3K27 demethylation, reprogramming, Kabuki syndrome, congenital heart disease
Location
X
Location
Species
Xp11.2 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
154.2 
7.56 
 
 
1401 
Entrez Protein:NP_066963
Uniprot:O15550
OMIM:300867
PubMed:23913813
PubMed:23665959
Annotation
X
Start
End
Domain
Description
93 
126 
TPR 
 
130 
163 
TPR 
 
205 
238 
TPR 
 
284 
317 
TPR 
 
318 
351 
TPR 
 
352 
385 
TPR 
 
1095 
1258 
JmjC 
 
Biological Process
X
GO ID
Term
Links
GO:0016577 
histone demethylation 
PubMed:17713478
PubMed:17761849
PubMed:17851529
pubmed:20300060
pubmed:22002947
GO:0045995 
regulation of embryonic development 
PubMed:17851529
GO:0006357 
regulation of transcription from RNA polymerase II promoter 
pubmed:21095589
GO:0009790 
embryo development 
pubmed:22713873
GO:0007281 
germ cell development 
pubmed: 22801502
GOIDHERE 
reprogramming 
pubmed:22801502
GO:0007507 
heart development 
pubmed:25972376
GO:0007420 
brain development 
pubmed:25972376
GOIDHERE 
craniofacial development 
pubmed:25972376
Molecular Function
X
GO ID
Term
Links
GOIDHERE 
histone demethylase activity (H3-K27 specific) 
pubmed:18003914
pubmed:22713873
GO:0035097 
histone methyltransferase complex 
pubmed:17500065
Other Function
X
Function
Links
mutated in cancer 
pubmed:19330029
pubmed:20054297
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
History
X
Created On
Last Changed
2007-09-19 14:03:19 
2007-09-19 14:13:46