Search the database for proteins containing a given motif or domain by clicking that domain/motif.
Links to INTERPRO, PROSITE, PFAM and SMART descriptions of that domain/motif appear where available.
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- JAB_MPN : - Domain in Jun kinase activation domain binding protein and proteasomal subunits INTERPRO SMART
- JmjC : - Jumonji C, a domain family that is part of the cupin metalloenzyme superfamily. SMART
- JmjN : - Small domain found in the jumonji family of transcription factors usually in conjunction with JmjC INTERPRO SMART
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K
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L
- L15 : - see ribosomal protein L15 PFAM INTERPRO
- L7Ae : - see ribosomal protein L7Ae PROSITE INTERPRO
- LEM : - domain in nuclear membrane-associated proteins INTERPRO SMART
- LER/SCAN : - highly conserved leucine rich region in C2H2-zinc finger proteins (also called the SCAN domain)INTERPRO SMART
- LRR : - Leucine-rich repeats may indicate protein-protein interaction domainINTERPRO SMART
- Leucine zipper : INTEPRO PROSITE
- LH2 : - Lipoxygenase homology 2 (beta barrel) domain (also called the PLAT domain) PFAM SMART
- ligand binding domain : - see HOLI, hormone receptor ligand binding domainPFAM SMART
- LIM : - Zinc-binding domain present in Lin-11, Isl-1, Mec-3 PFAM SMART
- LisH: - Lissencephaly type-1-like homology motif SMART
- LRR_RI : - Leucine rich repeat, ribonuclease inhibitor type SMART
- LRRcap : - occurring C-terminal to leucine-rich repeats INTERPRO SMART
- LXXLL : - The LXXLL motif (where L is leucine and X is any amino
acid) is present in RIP-140, SRC-1 and CBP is necessary and sufficient to mediate the binding of these proteins to liganded nuclear receptors
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- PAC
: -motif C-terminal to PAS motifs INTERPRO
SMART
- pah
: - pancreatic hormones / neuropeptide F / peptide YY family PFAM
SMART
- parp
: - poly(ADP-ribose) polymerase, catalytic region INTERPRO
PFAM
- PAS
: - domain found in signalling proteins, may act as signal sensor domain
INTERPRO SMART
- pax
: - paired box domain, usually (but not always) precedes a HOX domain
PFAM SMART
- PDZ
: - putative protein interaction domain present in PSD-95, Dlg, and ZO-1/2
PFAM SMART
- PH
: - pleckstrin
homology domain (found in eukaryotic signalling proteins) PFAM SMART
- PHD
finger : PFAM
SMART
: R. Aasland's PHD finger page
- PI3Kc
(PI3 kinase domain) : PFAM SMART
- PINc
:- predicted nucleotide-binding domain SMART
- pint
: - (PCI) domain in components of the proteasome, COP9-complex and eIF3
PFAM SMART
- POLBc
: - DNA polymerase type-B family PFAM
SMART
- polo
box : INTERPRO
PFAM
- POLXc
: - DNA polymerase X family PFAM
SMART
- polyA
: - PolyA_Cterm, C-terminal domain of Poly(A)-binding protein INTERPRO
SMART
- POP4
: - domain found in a protein subunit of human RNase MRP and RNase P
ribonucleoprotein complexes and archaeal proteins INTERPRO
SMART
- postSET
: - cysteine-rich motif following a subset of SET domains INTERPRO
SMART
- pou
: - domain in Pit-Oct-Unc transcription factors
PFAM SMART
- PP2Ac
: - protein phosphatase 2A homologues, catalytic domain. PFAM
SMART
- preSET
: - N-terminal to some SET domains INTERPRO
SMART
- pro_isomerase
(CSA PPIASE2) : - Peptidyl-prolyl cis-trans isomerase INTERPRO
PFAM
- proline
rich
- protamine
P1 : INTERPRO
PFAM
- protein
kinase C2 : PFAM
- pry
: - associated with SPRY domains SMART
- psp
: - proline-rich domain in spliceosome associated proteins SMART
- pth
: - Parathyroid hormone INTERPRO
SMART
- PTPc
: - protein tyrosine phosphatase, catalytic domain PFAM
SMART
- PUA
: - putative RNA-binding Domain in PseudoUridine synthase and Archaeosine
transglycosylase INTERPRO
SMART
- pumillo
RNA binding
- pur
: - DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical
proteins from Bacteroides-Cytophaga-Flexibacter bacteria SMART
- PWI
: - region found in proteins involved in splicing INTERPRO
SMART
- PWWP
: - putative protein-protein interaction domain PFAM
SMART
- PX
domain : - PhoX homologous domain, present in p47phox and p40phox PFAM
SMART
Q
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S
- S4 RNA binding domain : PFAM SMART
- Sam: - Sterile alpha motif, widespread domain in signalling and nuclear proteins PFAM SMART
- SAM Binding (SAM_Bind): - putative methyltransferase domain, S-Adenosyl-L-methionine (SAM) INTERPRO PROSITE
- SAND
: PFAM SMART
: R. Aasland's SAND page
- SANT
(myb-like DNA binding domain) : PFAM INTERPRO SMART
: R. Aasland's SANT page
- Sap :
- putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation INTERPRO SMART
- Sec63 :
- domain of unknown function in Sec63p, Brr2p and other proteins SMART
- S_TKc (ser/thr kinase) :
PFAM SMART
- STYKc (ser/thr/tyr kinase) :
- dual specificity kinase (e.g. CLK, PRP4K etc.) INTERPRO SMART
- SET :
- (Su(var)3-9, Enhancer-of-zeste, Trithorax) methyl transferase domain PFAM SMART
- SFM :
-splicing factor motif, present in Prp18 and Prp4 INTERPRO SMART
- sh2 :
- Src homology 2 domain, bind phosphotyrosine-containing polypeptides PFAM SMART
- sh3 :
- Src homology 3 domain, bind to target proteins through sequences containing proline and hydrophobic
amino acids PFAM SMART
- Skp1 :
- domain found in Skp1 family of proteins PFAM SMART
- Sm domain :
- Small nuclear ribonucleoprotein (Sm protein) INTERPRO PFAM
- small_GTPase :
- small GTPase of the Ras superfamily; ill-defined subfamily INTERPRO SMART
- SMC C term :
- domain is found at the C terminus of SMC proteins INTERPRO PFAM
- SMC N term :
- domain is found at the N terminus of SMC proteins INTERPRO PFAM
- SNF2 N term :
-SNF2 related domain INTERPRO PFAM
- spectrin repeat (SPEC) :
- found in several proteins involved in cytoskeletal structurPFAM SMART
- spry :
- domain in SPla and the RYanodine receptor PFAM SMART
- SR/RS:
serine/arginine repeats associated with proteins involved in splicing, targets of ser/thre kinases
- SRP14 :
- signal recognition particle, 14 kDa protein INTERPRO PFAM
- SRP19 :
- ribonucleoprotein complex SRP, Srp19 component INTERPRO PFAM
- SURP :
- domain in Suppressor-of-White-APricot (SWAP) INTERPRO PFAM
- swiB :
- BAF60b domain of the SWIB complex also found in the SWI/SNF complex 60 kda subunit and
prokaryotic DNA topoisomerases PFAM SMART
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- VWA
: - von Willebrand factor (vWF) type A domain PFAM
SMART
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W
- WAC
: - domain found in
N-terminus of WSTF/ACF/CT146 proteins
- WAKZ
: - domain adjacent
to PHD domain in WSTF/ACF/TIP5/WALp4 family of proteins
- WD40
: PFAM
SMART
- WW
: - (rsp5 or WWP domain)
PFAM SMART
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