acute lymphoblastic leukemia ALL, APB, ATM phosphorylation, BRCA1 nuclear dots, brct, cancer, chromosome breakage, chromosome instability, ds break repair, gene trap, homologous recombination, Ig class switching, immunodeficiency, Irradiation induced foci, MRE11, Nijmegen breakage syndrome, PML bodies, RAD50, radiation sensitivity, forkhead associated domain, alt, end resection
Interphase
repair foci
gene trap protein in foci in some cells, diffuse in most
Interphase
IR-induced foci
Complex with RAD50 and MRE1. To sites of P-H2A-X after damage
Interphase
telomere
Complex with TRF2 and telomeres in telomerase negative cells
S - meiosis
PML/ND10 bodies
Required to localise MRE11 in late S/G2 in telomerase negative cells
G2
PML/ND10 bodies
in telomerase negative cells
Interphase
T cell receptor alpha locus
in thymocytes
Interphase
immunoglobulin heavy-chain constant region
in B cells
S - interphase
replication foci
Interphase
ALT-associated PML body
Interphase
nucleolus
upon DNA damage