acute lymphoblastic leukemia ALL, APB, ATM phosphorylation, BRCA1 nuclear dots, brct, cancer, chromosome breakage, chromosome instability, ds break repair, gene trap, homologous recombination, Ig class switching, immunodeficiency, Irradiation induced foci, MRE11, Nijmegen breakage syndrome, PML bodies, RAD50, radiation sensitivity, forkhead associated domain, alt, end resection
Interphase
repair foci
gene trap protein in foci in some cells, diffuse in most
Interphase
IR-induced foci
Complex with RAD50 and MRE1. To sites of P-H2A-X after damage
Interphase
telomere
Complex with TRF2 and telomeres in telomerase negative cells
S - meiosis
PML/ND10 bodies
Required to localise MRE11 in late S/G2 in telomerase negative cells
G2
PML/ND10 bodies
in telomerase negative cells
Interphase
T cell receptor alpha locus
in thymocytes
Interphase
immunoglobulin heavy-chain constant region
in B cells
S - interphase
replication foci
Interphase
ALT-associated PML body
Interphase
nucleolus
upon DNA damage
105
190
BRCT (breast cancer susceptibility protein signatu
278
phosphorylated serine
phosphorylation site
343
phosphorylated serine
phosphorylation site by ATM
397
phosphorylated serine
phosphorylation site by ATM
615
phosphorylated serine
phosphorylation site by ATM
103
184
BRCT (breast cancer susceptibility protein signatu
GO:0006310
DNA recombination
GO:0007095
mitotic G2 checkpoint
GO:0006974
response to DNA damage stimulus
GO:0007004
telomerase-dependent telomere maintenance
GO:0016447
somatic recombination of antibody genes
GO:0006302
double-strand break repair
GO:0000724
double-strand break repair via homologous recombination
2001-01-05 16:20:36
2005-05-04 12:51:29