Cajal body, gem, genetic disease, nuclear mRNA splicing via spliceosome, methylated H3K79 binding
Interphase
gems
move from cytoplasm to nucleus in response to serum
Interphase
Cajal bodies
In most cultured cells and all 1o neurons. Requires sDMA-modified protein. Accumulates during diff.
Interphase
cytoplasmic
interact with the Sm core proteins
Interphase
nucleolar
gems in side nucleoli in half of adult tissues and 30% fetal tissues. Mutant form in nucleolus
Interphase
perinucleolar
SMN in large bodies at nucleolar perimeter in motor neurons. Nucleolar periphery on Pol I inhibition
90
149
tudor
SMA mutation E134K abolishes binding to Sm
GO:0030576
Cajal body organization and biogenesis
GO:0000398
nuclear mRNA splicing, via spliceosome
GO:0016074
snoRNA metabolism
GO:0003682
chromatin binding
GO:0035064
methylated histone residue binding
modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons
Yab8p
Schizosaccharomyces pombe