Names
X
Name
Species
Main
Sin3 
Homo sapiens, Mus musculus 
True 
Sin3a 
 
False 
Keywords
X
centromere protein, histone deacetylase complex, neocentromere, PAH, replication origin, repression complex, genetic disease, Witteveen-Kolk syndrome
Location
X
Location
Species
15q23 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
G1 
replication origins 
earliest origins of primary cells, targetting via RBBP1 
PubMed:11283269
S - interphase 
replication origins 
earliest origins of primary cells 
PubMed:11283269
G1 
perinucleolar 
earliest origins of primary cells 
PubMed:11283269
S - interphase 
perinucleolar 
earliest origins of primary cells 
PubMed:11283269
metaphase - mitosis 
centromere 
active centromeres and neocentromeres 
PubMed:14519686
metaphase - mitosis 
kinetochore 
 
PubMed:14519686
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
146.2 
6.84 
 
 
1282 
PubMed:10551834
PubMed:11106735
Entrez Nucleotide:L36831
PubMed:36758531
 
 
 
 
1273 
Entrez Protein:NP_056292
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006325 
establishment and/or maintenance of chromatin architecture 
PubMed:11238380
GO:0000122 
negative regulation of transcription from Pol II promoter 
PubMed:10734093
GO:0006342 
chromatin silencing 
pubmed:18995834
Molecular Function
X
GO ID
Term
Links
Other Function
X
Function
Links
essential 
PubMed:16055712
Expression
+
Related Genes
X
Name
Species
Links
Sin3 
Xenopus laevis 
PubMed:10454532
Entrez Nucleotide:AF154112
Sin3 
Saccharomyces cerevisiae 
PubMed:10655212
PubMed:10388812
PubMed:9234741
Sin3 
Caenorhabditis elegans 
PubMed:10904264
dSIN3 
Drosophila melanogaster 
PubMed:9799435
History
+