Names
Keywords
Location
Location
Species
17q21 
Homo sapiens 
11 
Mus musculus 
Subcellular Localisation
Stage
Description
Details
Links
Interphase 
BRCA1 nuclear dots 
Colocalises with FANCD2 
Interphase 
IR-induced foci 
localises to radiation induced foci (phosphorylated H2A-X) together with rad50, mre11, nbs 
S/G2 
repair foci 
after DNA damage with BLM 
Interphase 
inactive X 
Necessary for localising XIST 
Interphase 
ALT-associated PML body 
 
Interphase 
chromatin 
BRCA1-IRES isoform 
pachytene 
XY body 
 
Interphase 
centrosome 
after microtubule damage 
Interphase 
nucleolus 
 
Protein Sequence
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
Annotation
Biological Process
GO ID
Term
Links
GO:0006338 
chromatin remodeling 
GO:0006342 
chromatin silencing 
GO:0006302 
double-strand break repair 
GO:0000122 
negative regulation of transcription from Pol II promoter 
GO:0006283 
transcription-coupled nucleotide-excision repair 
GO:0000067 
DNA replication and chromosome cycle 
GO:0000019 
regulation of mitotic recombination 
GO:0006357 
regulation of transcription from Pol II promoter 
GO:0070870 
heterochromatin maintenance involved in chromatin silencing 
GO:2000730 
regulation of termination of RNA polymerase I transcription 
GO:0097681 
double-strand break repair via alternative nonhomologous end joining 
GO:0048478 
replication fork protection 
GO:0017148 
negative regulation of translation 
Molecular Function
GO ID
Term
Links
GO:0003677 
DNA binding 
GO:0003723 
RNA binding 
GO:0004842 
ubiquitin-protein ligase activity 
GO:0035518 
histone H2A monoubiquitination 
Other Function
Function
Links
chromosome instability in -/- cells 
Expression
Experiment
Detail
Links
Related Genes
Name
Species
Links
brc-1 
Caenorhabditis elegans 
History
Created On
Last Changed
2001-04-12 13:54:13 
2005-11-02 14:55:39