cancer, chromosome instability, ds breakage, exonuclease, genetic disease, helicase, DNA replication, heterochromatin, RNA polymerase I, telomere, nucleolus, senescence, G-Quadruplex
Interphase
nucleolus
only in proliferating human cells. Nucleoplasmic in serum starved cell, after ActD, + in the mouse.
S - meiosis
repair foci
with RP-A in hydroxyurea arrested cells
Interphase
repair foci
with RPA and rad51 after DNA damage. Partial co-localisation with PML bodies
GO:0006261
DNA-dependent DNA replication
GO:0006312
mitotic recombination
GO:0000723
telomere maintenance
GO:0006360
transcription from Pol I promoter
GO:1902153
regulation of response to DNA damage checkpoint signaling
GO:0070828
heterochromatin organization
GO:0008408
3.-5. exonuclease activity
GO:0003684
damaged DNA binding
GO:0003678
DNA helicase activity
GO:0044806
G-quadruplex DNA unwinding
Sgs1
Saccharomyces cerevisiae
Rqh1
Schizosaccharomyces pombe
2001-04-23 13:06:09
2006-07-13 16:14:51