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Names
X
Name
Species
Main
DNA topoisomerase I
False
TOP1
Homo sapiens
False
topoisomerase I
Homo sapiens, Mus musculus
True
Keywords
X
chromosome scaffold, genome stability, DNA replication, mitotic chromosomes, mRNA splicing, topoisomerase, ribonucleotide excision repair, RER
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
nucleolus
In granular component with p14ARF
PubMed:11314011
PubMed:12429849
Mitosis
chromosomal
PubMed:15609038
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
90.8
9.33
765
Entrez Protein:P11387
PubMed:98155246
OMIM:126420
Uniprot:P11387
766
Entrez Protein:NP_033434
Uniprot:Q04750
Annotation
X
Start
End
Domain
Description
59
62
NLS
88
105
NLS BP
135
179
NLS BP
188
197
NLS
360
737
TOPEUc
Biological Process
X
GO ID
Term
Links
GO:0006376
mRNA splice site selection
PubMed:8609994
pubmed:20862310
GOIDHERE
maintenance of genome stability
pubmed:19838172
pubmed:20862310
GO:0048478
replication fork protection
pubmed:19838172
GO:0050684
regulation of mRNA processing
pubmed: 20862310
GO:1990516
ribonucleotide excision repair
pubmed:23375499
Molecular Function
X
GO ID
Term
Links
GO:0003917
DNA topoisomerase type I activity
PubMed:98155254
Other Function
X
Function
Links
Expression
+
Related Genes
X
Name
Species
Links
TOP1
Caenorhabditis elegans
PubMed:1131887
History
+