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Names
X
Name
Species
Main
B23
Homo sapiens, Mus musculus
False
NO38
Homo sapiens, Mus musculus
False
NPM1
False
nucleophosmin 1
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus laevis
True
numatrin
Homo sapiens
False
Keywords
X
AML, APL, chromosome scaffold, granular component, inositol_1 4 5_triphosphate receptor activity, insulation, leukaemia, leukaemia_associated translocation, mitotic chromosomes, NDF, non_Hodgkin lymphoma, ribosome assembly, nucleolus, centrosome, ubiquitin-dependent protein degradation, ribosome export, mutated in cancer, haemopoiesis, chromatin decondensation, autophagy
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
nucleolus
Rapid exchange between nucleolus and nucleoplasm
PubMed:11285283
PubMed:10931858
PubMed:12429849
PubMed:15635413
PubMed:17517959
Interphase
centrosome
associates with unduplicated centrosomes.Dissociates by cdk2/cyclinE phosphorylation
PubMed:11051553
telophase
nucleolus derived foci
PubMed Central:9725903
anaphase - mitosis
chromosome surface
PubMed:9725903
Mitosis
chromosome surface
PubMed:15609038
Interphase
cytoplasmic
in AML
pubmed:18625840
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
32.6
4.64
38
294
Entrez Protein:P06748
PubMed:15870172
OMIM:164040
Uniprot:P06748
PubMed:19569254
PubMed:23435463
292
Entrez Protein:NP_032748
Uniprot:Q61937
292
Entrez Protein:P13084
Uniprot:P13084
294
Entrez Protein:P16039
Uniprot:P16039
299
Entrez Protein:P07222
Uniprot:P07222
Annotation
X
Start
End
Domain
Description
141
157
NLS BP
Biological Process
X
GO ID
Term
Links
GO:0006341
chromatin insulator sequence binding
PubMed:14759373
GO:0006338
chromatin remodeling
PubMed:14759373
GO:0006323
DNA packaging
PubMed:11602260
GO:0043066
negative regulation of apoptosis
PubMed:15310764
PubMed:15684379
PubMed:15893727
GO:0007000
nucleolus organization and biogenesis
PubMed:15684379
GO:0032434
regulation of proteasomal ubiquitin-dependent protein catabolic process
pubmed:18625840
GO:0051168
ribosome export from nucleus
pubmed:18809582
GO:0060188
regulation of protein desumoylation
pubmed:19015314
GO:0060218
hematopoietic stem cell differentiation
pubmed:16007073
GO:0035041
sperm chromatin decondensation
pubmed:22362753
GO:0006914
autophagy
pubmed:25754892
Molecular Function
X
GO ID
Term
Links
GO:0008095
inositol-1,4,5-triphosphate receptor activity
PubMed:15893727
GO:0003676
nucleic acid binding
Entrez Protein:P06748
GO:0003762
nucleosome assembly chaperone
PubMed:11602260
Other Function
X
Function
Links
essential
PubMed:16007073
PubMed:16199867
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
History
+