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Names
X
Name
Species
Main
DNA (cytosine-5-)-methyltransferase 3a
Homo sapiens, Mus musculus
False
DNMT3a
Homo sapiens, Mus musculus
True
ES485
Mus musculus
False
Keywords
X
growth, dna methylase, gene trap, histone deacetylase complex, histone methylation, PWWP domain, mitotic chromosomes, repression complex, transcription repression, methyl-lysine binding, ADD domain, transcription elongation, H3K36me3 binding, genetic disease, acute leukemia, cancer, differentiation, mutated in cancer, AML, Tatton-Brown-Rahman syndrome, overgrowth
Location
X
Location
Species
12
Mus musculus
2p23
Homo sapiens
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
heterochromatin
PubMed:11427539
PubMed:15456878
Interphase
nuclear diffuse
gene -trap is nuclear diffuse. Dnmt3a2 isoform is also diffuse over chromatin
PubMed:12138111
Mitosis
chromosomal
depends on PWWP domain
PubMed:14998998
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
101.9
6.19
912
Entrez Protein:NP_072046
Uniprot:Q9Y6K1
PubMed:21067377
PubMed:21415852
PubMed:24614070
PubMed:24656771
101.7
6.27
908
Entrez Protein:NP_031898
Uniprot:O88508
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006338
chromatin remodeling
PubMed:12711675
GO:0006306
DNA methylation
PubMed:10555141
PubMed Central:10805783
GO:0006346
methylation-dependent chromatin silencing
PubMed:11350943
pubmed: 22584578
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
pubmed:20651149
GO:0048863
stem cell differentiation
pubmed:22138693
Molecular Function
X
GO ID
Term
Links
GO:0003886
DNA (cytosine-5-)-methyltransferase activity
PubMed:10555141
PubMed:11399089
PubMed Central:10805783
GO:0035064
methylated histone residue binding
pubmed:20547484
Other Function
X
Function
Links
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
History
+