DNA (cytosine-5-)-methyltransferase 3a
Homo sapiens, Mus musculus
False
DNMT3a
Homo sapiens, Mus musculus
True
growth, dna methylase, gene trap, histone deacetylase complex, histone methylation, PWWP domain, mitotic chromosomes, repression complex, transcription repression, methyl-lysine binding, ADD domain, transcription elongation, H3K36me3 binding, genetic disease, acute leukemia, cancer, differentiation, mutated in cancer, AML, Tatton-Brown-Rahman syndrome, overgrowth
Interphase
heterochromatin
Interphase
nuclear diffuse
gene -trap is nuclear diffuse. Dnmt3a2 isoform is also diffuse over chromatin
Mitosis
chromosomal
depends on PWWP domain
1
209
gene trap insertion
GO:0006338
chromatin remodeling
GO:0006306
DNA methylation
GO:0006346
methylation-dependent chromatin silencing
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
GO:0048863
stem cell differentiation
GO:0003886
DNA (cytosine-5-)-methyltransferase activity
GO:0035064
methylated histone residue binding