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Names
X
Name
Species
Main
HIF-1 alpha
Homo sapiens, Mus musculus
True
MOP1
False
bHLHe78
false
PASD8
false
HIF-1A
false
HIF1 alpha
false
HIF1A
false
Keywords
X
nucleolus, hydroxyproline, transcription factor, ubiquitin, HLH, pas domain, hypoxia, sumoylated, adipogenesis, vascular development
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
nuclear diffuse
Heterodimer with HIF1-beta.
Interphase
nucleolus
sequestered to nucleolus by p14ARF
PubMed:11382768
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
95.5
5.17
850
Entrez Protein:NP_001230013
PubMed:11313887
Uniprot:Q16665
91.9
5.17
822
Entrez Protein:Q61221
Uniprot:Q61221
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006357
regulation of transcription from Pol II promoter
PubMed Central:10758161
GO:0032364
oxygen homeostasis
pubmed:7539918
GO:0060612
adipose tissue development
pubmed:11879638
Molecular Function
X
GO ID
Term
Links
GO:0003677
DNA binding
PubMed Central:10758161
GO:0003704
specific RNA polymerase II transcription factor activity
PubMed Central:10758161
Other Function
X
Function
Links
angiogenesis, erythropoiesis and glycolysis
PubMed Central:10758161
induction of oxygen regulated genes. Heterodimer with HIF1-beta.
PubMed Central:10758161
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
HIF-1 alpha
Caenorhabditis elegans
PubMed:11427734
History
X
Created On
Last Changed
2001-07-12 11:03:19
2004-12-02 15:29:43