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Names
X
Name
Species
Main
Top IIIa
Homo sapiens
False
Topo IIIalpha
Homo sapiens, Mus musculus
False
topoisomerase III alpha
Homo sapiens, Mus musculus
True
TP3A
Homo sapiens, Mus musculus
False
Top3A
false
Keywords
X
homologous recombination, Holliday junction resolvase, PML bodies, topoisomerase, zinc finger C2HC, meiotic recombination, alt telomere pathway, BTR complex
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
PML/ND10 bodies
co-localisation and interaction with BLM
PubMed:10728666
PubMed:16199871
Interphase
mitochondria
PubMed:12209014
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
112.4
8.69
1001
OMIM:601243
Entrez Protein:NP_004609
112.4
8.73
1003
Entrez Protein:NP_033436
Annotation
X
Start
End
Domain
Description
35
169
TOPRIM
172
269
TOP1Bc
286
289
NLS
315
569
TOP1Ac
656
672
NLS BP
965
968
NLS
979
983
NLS
983
999
C2HC Zn finger
35
169
TOPRIM
172
269
TOP1Bc
315
569
TOP1Ac
656
672
NLS BP
967
970
NLS
981
985
NLS
985
1001
C2HC Zn finger
Biological Process
X
GO ID
Term
Links
GO:0006310
DNA recombination
PubMed:10728666
GO:0000019
regulation of mitotic recombination
PubMed:14685245
pubmed:25699707
GO:0071139
resolution of recombination intermediates
pubmed:16595695
GO:0000722
telomere maintenance via recombination
pubmed: 28877996
pubmed:31138797
Molecular Function
X
GO ID
Term
Links
GO:0003916
DNA topoisomerase activity
PubMed:10728666
GO:0048476
Holliday junction resolvase complex
pubmed:14685245
pubmed:17728255
Other Function
X
Function
Links
homozygous lethal
PubMed: 9448276
Expression
+
Related Genes
X
Name
Species
Links
TP3A
Drosophila melanogaster
Entrez Protein:Q9NG98
History
X
Created On
Last Changed
2001-07-12 16:34:06
2004-04-08 12:08:54