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Names
X
Name
Species
Main
ERCC1
Homo sapiens, Mus musculus
True
COFS4
false
RAD10
false
UV20
false
Keywords
X
chromosome instability, endonuclease, HHH, nucleotide excision repair, photosensitivity, structure-specific nuclease, interstrand crosslinks, DNA repair
Location
X
Location
Species
19q13.32
Homo sapiens
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
nuclear diffuse
immobilised for 4 mins after induction of DNA damage
PubMed:10320375
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
35.4
5.9
323
Uniprot:P07992
Entrez Protein:NP_973730
298
Entrez Protein:P07903
Uniprot:P07903
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006310
DNA recombination
PubMed:11707424
GO:0006281
DNA repair
PubMed:10320375
GO:0006289
nucleotide-excision repair
PubMed:11160918
GO:0036297
interstrand cross-link repair
pubmed:21896658
Molecular Function
X
GO ID
Term
Links
GO:0003686
DNA repair enzyme
PubMed:NA11160918
GO:0003685
DNA repair protein
PubMed:11160918
GO:0004519
endonuclease activity
PubMed:11160918
Other Function
X
Function
Links
maintenance of genomic stability
PubMed:9427687
PubMed:9197240
structure-specific nuclease with two subunits, ERCC1 and XPF. The enzyme cuts DNA at junctions where a single strand moves 5. to 3. away from a branch point with duplex DNA
PubMed:11160918
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
rad10
Saccharomyces cerevisiae
Uniprot:P06838
swi10
Schizosaccharomyces pombe
Uniprot:Q06182
History
+