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Names
X
Name
Species
Main
emerin
Homo sapiens, Mus musculus, Rattus norvegicus
True
Keywords
X
genetic disease, integral membrane protein, mitotic chromosomes, nuclear periphery, ERK signalling, lem domain
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
inner nuclear membrane
relocalised to ER in lamin A- cells
PubMed:10579712
PubMed:10732816
PubMed:10671368
PubMed:11269947
telophase
chromosome surface
reforming nuclear envelope around chromosomes - at "core" regions close to spindle
PubMed:10671368
Interphase
inner nuclear membrane
relocalised to cytoplasm when laminA/C silenced by siRNA in human endometrial cells
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
29
5.29
34
254
Entrez Protein:NP_000108
PubMed:11435115
OMIM:310300
Uniprot:P50402
259
Uniprot:O08579
Entrez Protein:NP_031953
pubmed:
260
Uniprot:Q63190
Annotation
X
Start
End
Domain
Description
2
45
lem
binding to baf
31
47
NLS BP
229
245
transmembrane
Biological Process
X
GO ID
Term
Links
GO:0007517
muscle development
PubMed:310300
PubMed:16403804
GO:0006998
nuclear membrane organization and biogenesis
PubMed:11269947
PubMed:11792821
PubMed:16115958
GO:0070372
negative regulation of ERK1 and ERK2 cascade
pubmed:19720741
Molecular Function
X
GO ID
Term
Links
Other Function
X
Function
Links
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
emr-1
Caenorhabditis elegans
PubMed Central:10982402
History
X
Created On
Last Changed
2001-07-25 14:59:07
2006-03-06 09:32:26